At present, the safety evaluation of the road is often concerned with historical crashes. Nevertheless, it is difficult to effectively evaluate the safety of the road before its reconnaissance, design and construction. With the continuous development of driving simulation technology, it has been widely used in safety assessment of proposed roads, but an effective safety evaluation model is still needed to standardize this process. Based on a full-scale driving simulator, the research virtualizes the scene of Wu-liu highway, generating a virtual highway consistent with the geometric conditions of Wuliu highway, driving data was collected in the driving simulator, analyzed the driving situations of different sections. The aim of which is to identify accident-prone sections and establish an evaluation system for comfort as well as safety from both the subjective and objective point of view. The objective safety evaluation includes seven kinds of indexes. The subjective safety evaluation of the road includes an evaluation of agreeableness, comfort and consistency. Based on Analytic Hierarchy Model (AHM) method, the safety level of the road can be calculated. Furthermore, the method will play a significant role in highway construction and operations management in the future.